Potentially fatal severe brady arrythmias related to Lopinavir-Ritonavir in a COVID 19 patient

The lopinavir/ritonavir-associated rise in lipids is not related to lopinavir or ritonavir plasma concentration.

BACKGROUND The relationship between lopinavir plasma concentration and the magnitude of lipid elevation after initiation of lopinavir/ritonavir-containing antiretroviral therapy is unclear. The aim of this study was to determine the relationship between drug concentration and lipid changes in two patient cohorts. METHODS First, we analysed, in an outpatient cohort, the correlation between per...

Lopinavir/ritonavir in pregnancy Introduction

Severe dyslipidaemia after the addition of raltegravir to a lopinavir/ritonavir-containing regimen.

We describe a 55-year-old HIV-1-infected male who developed severe dyslipidaemia (total cholesterol 600 mg/dl, triglycerides >5,000 mg/dl, high density lipoprotein <5 mg/dl) after raltegravir was added to his lopinavir/ritonavir-containing regimen. To our knowledge, this is the first reported case of severe dyslipidaemia associated with the addition of raltegravir to a lopinavir/ritonavir-based...

Lopinavir/Ritonavir: A Review for 2011

Ritonavir-boosted lopinavir (LPV/r) is a boosted protease inhibitor (PI) combination used as an alternative agent in the management of the human immunodeficiency virus (HIV). HIV treatment consists of combinations of classes of medications with complementing mechanisms of action. Protease inhibitor-based therapy is one of the mainstays of therapy. Ritonavir-boosted lopinavir can be dosed onceor...

Caring Behaviors Related to COVID-19: A Cross-Sectional Study in the Eastern of Iran

Background: Some recommendations and health protocols were presented for controlling COVID-19 after the outbreak such as the use of face masks, observing social distance, closure of schools, and etc. Despite these protocols, we witnessed different peaks and variants of COVID-19 during more than two years.This study investigated some risky behaviors such as not wearing face masks, violating soci...